Genetic and Circulating Biomarker Data Improve Risk Prediction for Pancreatic Cancer in the General Population.

ABSTRACT:

Background

Pancreatic cancer is the third leading cause of cancer death in the United States, and 80% of patients present with advanced, incurable disease. Risk markers for pancreatic cancer have been characterized, but combined models are not used clinically to identify individuals at high risk for the disease.

Methods

Within a nested case-control study of 500 pancreatic cancer cases diagnosed after blood collection and 1,091 matched controls enrolled in four U.S. prospective cohorts, we characterized absolute risk models that included clinical factors (e.g., body mass index, history of diabetes), germline genetic polymorphisms, and circulating biomarkers.

Results

Model discrimination showed an area under ROC curve of 0.62 via cross-validation. Our final integrated m

SUBMITTER: Kim J 

PROVIDER: S-EPMC8020898 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature