Maternal-Fetal Immune Responses in Pregnant Women Infected with SARS-CoV-2.

ABSTRACT: Pregnant women are a high-risk population for severe/critical COVID-19 and mortality. However, the maternal-fetal immune responses initiated by SARS-CoV-2 infection, and whether this virus is detectable in the placenta, are still under investigation. Herein, we report that SARS-CoV-2 infection during pregnancy primarily induced specific maternal inflammatory responses in the circulation and at the maternal-fetal interface, the latter being governed by T cells and macrophages. SARS-CoV-2 infection during pregnancy was also associated with a cytokine response in the fetal circulation (i.e. umbilical cord blood) without compromising the cellular immune repertoire. Moreover, SARS-CoV-2 infection neither altered fetal cellular immune responses in the placenta nor induced elevated cord blood lev

SUBMITTER: Garcia-Flores V 

PROVIDER: S-EPMC8020997 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature