Ontology highlight
ABSTRACT:
SUBMITTER: Kasetti RB
PROVIDER: S-EPMC8021112 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Kasetti Ramesh B RB Maddineni Prabhavathi P Kiehlbauch Charles C Patil Shruti S Searby Charles C CC Levine Beth B Sheffield Val C VC Zode Gulab S GS
JCI insight 20210308 5
Elevation of intraocular pressure (IOP) due to trabecular meshwork (TM) damage is associated with primary open-angle glaucoma (POAG). Myocilin mutations resulting in elevated IOP are the most common genetic causes of POAG. We have previously shown that mutant myocilin accumulates in the ER and induces chronic ER stress, leading to TM damage and IOP elevation. However, it is not understood how chronic ER stress leads to TM dysfunction and loss. Here, we report that mutant myocilin activated autop ...[more]