Ontology highlight
ABSTRACT:
SUBMITTER: Andersen CL
PROVIDER: S-EPMC8021246 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Andersen Courtney L CL Tobias Joseph D JD
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG 20210331 3
Diphenhydramine (Benadryl) is a first-generation antihistamine that is used primarily to treat allergic reactions including anaphylaxis, urticaria, and allergic rhinitis. Despite its availability as an over-the-counter medication, toxicity may occur with its use especially when administered in large doses or via the intravenous route. We present a 3-month-old infant with Trisomy 21 who suffered a cardiac arrest immediately following administration of a single 1.25 mg/kg dose of intravenous diphe ...[more]