The systemic treatment of uterine leiomyosarcomas: A systematic review. No news is good news?

ABSTRACT:

Background

Uterine leiomyosarcomas are rare malignant mesenchymal tumors. The systemic treatment of these tumors includes chemotherapy and radiotherapy. However, there are still a lot of unanswered questions regarding the ideal therapeutic approach.

Methods

We have conducted a systematic review of the treatment strategies of uterine leiomyosarcomas for the last ten years.

Results

Adjuvant chemotherapy is still a matter of dilemma. Doxorubicin based chemotherapy or the combination of Gemcitabine-Docetaxel are the regimens of choice for the first line setting. Beyond the first line, there are several options;, including chemotherapy, targeted therapy, and recently efforts of introducing immunotherapy to the therapeutic armamentarium of clinicians treating uterine leiomy

SUBMITTER: Kyriazoglou A 

PROVIDER: S-EPMC8021365 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature