Association of Non-Steroidal Anti-Inflammatory Drugs with Kidney Health in Ambulatory Older Adults.

ABSTRACT:

Background/objectives

Non-steroidal anti-inflammatory drugs (NSAIDs) can cause kidney injury, especially in older adults. However, previously reported associations between NSAID use and kidney health outcomes are inconsistent and limited by reliance on serum creatinine-based GFR estimates. This analysis investigated the association of NSAID use with kidney damage in older adults using multiple kidney health measures.

Design

Cross-sectional and longitudinal analyses.

Setting

Multicenter, community-based cohort.

Participants

Two thousand nine hundred and ninty nine older adults in the Health ABC Study. A subcohort (n = 500) was randomly selected for additional biomarker measurements.

Exposure

Prescription and over-the-counter NSAID use ascertained by self-

SUBMITTER: Amatruda JG 

PROVIDER: S-EPMC8021485 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature