Sphingosine-kinase-1 expression is associated with improved overall survival in high-grade serous ovarian cancer.

ABSTRACT:

Purpose

Sphingosine-kinase-1 (SPHK1) is a key enzyme of sphingolipid metabolism which is involved in ovarian cancer pathogenesis, progression and mechanisms of drug resistance. It is overexpressed in a variety of cancer subtypes. We investigated SPHK1 expression as a prognostic factor in epithelial ovarian cancer patients.

Methods

Expression analysis of SPHK1 was performed on formalin-fixed paraffin-embedded tissue from 1005 ovarian cancer patients with different histological subtypes using immunohistochemistry. Staining intensity of positive tumor cells was assessed semi-quantitatively, and results were correlated with clinicopathological characteristics and survival.

Results

In our ovarian cancer collective, high levels of SPHK1 expression correlated significantly w

SUBMITTER: Hanker LC 

PROVIDER: S-EPMC8021516 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature