Developmental influences on symptom expression in antipsychotic-naive first-episode psychosis.

ABSTRACT:

Background

The neurodevelopmental model of psychosis was established over 30 years ago; however, the developmental influence on psychotic symptom expression - how age affects clinical presentation in first-episode psychosis - has not been thoroughly investigated.

Methods

Using generalized additive modeling, which allows for linear and non-linear functional forms of age-related change, we leveraged symptom data from a large sample of antipsychotic-naïve individuals with first-episode psychosis (N = 340, 12-40 years, 1-12 visits), collected at the University of Pittsburgh from 1990 to 2017. We examined relationships between age and severity of perceptual and non-perceptual positive symptoms and negative symptoms. We tested for age-associated effects on change in

SUBMITTER: Bridgwater M 

PROVIDER: S-EPMC8021611 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature