Preparation, optimization, and evaluation of midazolam nanosuspension: enhanced bioavailability for buccal administration.

ABSTRACT: Midazolam is considered as one of the best first-line drugs in managing status epilepticus in children who require emergency drug treatment. Due to poor water solubility, oral bioavailability of midazolam is relatively low. To improve its dissolution and absorption, midazolam nano-suspensions were formulated with different stabilizers using the ultrasonic technique. A combination of Tween 80 and Poloxamer (TP) was considered as one stabilizer and 3-methyl chitosan (TMC) as another stabilizer. The ratio of the stabilizers was selected as an independent variable, and their effects on the particle size and the zeta potential were evaluated by the simplex lattice mixture method. The freeze-dried optimized midazolam nano-suspension powder was characterized by particle-size analysis, SEM, the st

SUBMITTER: Soroushnia A 

PROVIDER: S-EPMC8021663 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature