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Current strategies to circumvent the antiviral immunity to optimize cancer virotherapy.

ABSTRACT: Cancer virotherapy is a paradigm-shifting treatment modality based on virus-mediated oncolysis and subsequent antitumor immune responses. Clinical trials of currently available virotherapies showed that robust antitumor immunity characterizes the remarkable and long-term responses observed in a subset of patients. These data suggest that future therapies should incorporate strategies to maximize the immunotherapeutic potential of oncolytic viruses. In this review, we highlight the recent evidence that the antiviral immunity of the patients may limit the immunotherapeutic potential of oncolytic viruses and summarize the most relevant approaches to strategically redirect the immune response away from the viruses and toward tumors to heighten the clinical impact of viro-immunotherapy platforms.

SUBMITTER: Shin DH

PROVIDER: S-EPMC8021759 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Current strategies to circumvent the antiviral immunity to optimize cancer virotherapy.

Shin Dong Ho DH Nguyen Teresa T Ozpolat Bulent B Lang Frederick F Alonso Marta M Gomez-Manzano Candelaria C Fueyo Juan J

Journal for immunotherapy of cancer 20210401 4

Cancer virotherapy is a paradigm-shifting treatment modality based on virus-mediated oncolysis and subsequent antitumor immune responses. Clinical trials of currently available virotherapies showed that robust antitumor immunity characterizes the remarkable and long-term responses observed in a subset of patients. These data suggest that future therapies should incorporate strategies to maximize the immunotherapeutic potential of oncolytic viruses. In this review, we highlight the recent evidenc ...[more]

PMID: 33795384

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