Hypertension and Atrial Fibrillation: A Study on Epidemiology and Mendelian Randomization Causality.

ABSTRACT: Introduction: Hypertension (HT) and atrial fibrillation (AF) often coexist. However, the causality between these two conditions remains to be determined. Methods: We used individual participant data from the Atherosclerosis Risk in Communities (ARIC) prospective cohort with 9,474 participants. HT was ascertained at visit 1 (1987-1989), and incident AF was identified by ECGs conducted during study examinations at each visit, hospital discharge codes, and death certificates. We used the Kaplan-Meier estimate to compute the cumulative incidence of AF by the HT subgroup. Then we used Cox hazard regression model to assess the association between HT and incident AF. The causality between genetically determined HT and AF was analyzed by the two-sample Mendelian randomization (MR) ba

SUBMITTER: Liao LZ 

PROVIDER: S-EPMC8021766 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature