Integrated Analysis of ceRNA Regulatory Network Associated With Tumor Stage in Cervical Cancer.

ABSTRACT:

Objective

To analyze the abnormally expressed genes involved in cervical cancer occurrence and development.

Materials and methods

Integrated bioinformatics methods were used to analyze differentially expressed (DE) RNAs, including mRNAs, microRNAs (miRNAs), and long non-coding RNAs (lncRNAs), in stage I, II, III, and IV cervical cancer patients from the TCGA database to fully reveal the dynamic changes caused by cervical cancer.

Results

First, DE RNAs in cervical cancer tissues from stage I, II, III, and IV patients and normal cervical tissues were identified and divided into different profiles. Several DE RNA profiles were down-regulated or up-regulated in stage I, III, and IV patients. GO and KEGG analysis of DE mRNA profile 1, 2, 4, 5, 6 and 22 which were significa

SUBMITTER: Ma X 

PROVIDER: S-EPMC8021857 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature