Metabolomic characterization of colorectal cancer cell lines highlighting stage-specific alterations during cancer progression.

ABSTRACT: Introduction: Metabolomic studies on various colorectal cancer (CRC) cell lines have improved our understanding of the biochemical events underlying the disease. However, the metabolic profile dynamics associated with different stages of CRC progression is still lacking. Such information can provide further insights into the pathophysiology and progression of the disease that will prove useful in identifying specific targets for drug designing and therapeutics. Thus, our study aims to characterize the metabolite profiles in the established cell lines corresponding to different stages of CRC. Methods: Metabolite profiling of normal colon cell lines (CCD 841 CoN) and CRC cell lines corresponding to different stages, i.e., SW 1116 (stage A), HT 29 and SW 480 (stage

SUBMITTER: Yusof HM 

PROVIDER: S-EPMC8022234 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature