Distinct tumor bacterial microbiome in lung adenocarcinomas manifested as radiological subsolid nodules.

ABSTRACT:

Objectives

Increasing evidence indicates that microbiota dysbiosis in the human body may play vital roles in carcinogenesis. However, the relationship between microbiome and lung cancer remains unclear. In this study, we aimed to characterize the microbiome in early stage of lung adenocarcinoma (LUAD), which presented as subsolid nodules (SSN) or solid nodules (SN).

Materials and methods

We performed 16S rRNA sequencing of 35 pairs (10 SSN and 25 SN) of LUAD tumor tissues and paired adjacent normal tissues. Machine learning was used to identify microbial signatures and construct predictive models.

Results

SSN has higher microbiome richness and diversity compared with SN (richness p = 0.017, Shannon index p = 0.17), and the microbiome composition of SSN is distinct fro

SUBMITTER: Ma Y 

PROVIDER: S-EPMC8022255 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature