Association of Intravenous Radiocontrast With Kidney Function: A Regression Discontinuity Analysis.

ABSTRACT:

Importance

Radiocontrast has long been thought of as nephrotoxic; however, a number of recent observational studies found no evidence of an association between intravenous contrast and kidney injury. Because these studies are at high risk of confounding and selection bias, alternative study designs are required to enable more robust evaluation of this association.

Objective

To determine whether intravenous radiocontrast exposure is associated with clinically significant long-term kidney impairment, using a study design that permits stronger causal interpretation than existing observational research.

Design, setting, and participants

This cohort study included all emergency department patients aged 18 years or older undergoing D-dimer testing between 2013 and 2018 in t

SUBMITTER: Goulden R 

PROVIDER: S-EPMC8022267 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature