Epileptogenesis-induced changes of hippocampal-piriform connectivity.

ABSTRACT:

Objective

Tissue remodeling has been described in brain circuits that are involved in the generation and propagation of epileptic seizures. Human and animal studies suggest that the anterior piriform cortex (aPC) is crucial for seizure expression in focal epilepsies. Here, we investigate the effect of kainic-acid (KA)-induced seizures on the effective connectivity of the aPC with bilateral hippocampal CA3 regions using cerebro-cerebral evoked potentials (CCEPs).

Methods

Adult male Sprague-Dawley rats were implanted with a tripolar electrode in the left aPC for stimulation and recording, and with unipolar recording electrodes in bilateral CA3 regions. Single pulse stimulations were given to the aPC and CCEPs were averaged before KA injections and after the emergence of sponta

SUBMITTER: Skopin MD 

PROVIDER: S-EPMC8022328 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature