Gut microbiota-derived inosine from dietary barley leaf supplementation attenuates colitis through PPARγ signaling activation.

ABSTRACT:

Background

Ulcerative colitis is a type of chronic inflammatory bowel disease closely associated with gut microbiota dysbiosis and intestinal homeostasis dysregulation. Barley leaf (BL) has a long history of use in Traditional Chinese Medicine with potential health-promoting effects on intestinal functions. However, its mechanism of action is not yet clear. Here, we explore the potential modulating roles of gut microbial metabolites of BL to protect against colitis and elucidate the underlying molecular mechanisms.

Results

Using 16S rRNA gene-based microbiota analysis, we first found that dietary supplementation of BL ameliorated dextran sulfate sodium (DSS)-induced gut microbiota dysbiosis. The mechanisms by which BL protected against DSS-induced colitis were resulted from

SUBMITTER: Li D 

PROVIDER: S-EPMC8022418 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature