Roles for RNA export factor, Nxt1, in ensuring muscle integrity and normal RNA expression in Drosophila.

ABSTRACT: The mRNA export pathway is responsible for the transport of mRNAs from the nucleus to the cytoplasm, and thus is essential for protein production and normal cellular functions. A partial loss of function allele of the mRNA export factor Nxt1 in Drosophila shows reduced viability and sterility. A previous study has shown that the male fertility defect is due to a defect in transcription and RNA stability, indicating the potential for this pathway to be implicated in processes beyond the known mRNA transport function. Here we investigate the reduced viability of Nxt1 partial loss of function mutants, and describe a defect in growth and maintenance of the larval muscles, leading to muscle degeneration. RNA-seq revealed reduced expression of a set of mRNAs, particularly from genes with long in

SUBMITTER: van der Graaf K 

PROVIDER: S-EPMC8022728 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature