A telomere-to-telomere assembly of Oscheius tipulae and the evolution of rhabditid nematode chromosomes.

ABSTRACT: Eukaryotic chromosomes have phylogenetic persistence. In many taxa, each chromosome has a single functional centromere with essential roles in spindle attachment and segregation. Fusion and fission can generate chromosomes with no or multiple centromeres, leading to genome instability. Groups with holocentric chromosomes (where centromeric function is distributed along each chromosome) might be expected to show karyotypic instability. This is generally not the case, and in Caenorhabditis elegans, it has been proposed that the role of maintenance of a stable karyotype has been transferred to the meiotic pairing centers, which are found at one end of each chromosome. Here, we explore the phylogenetic stability of nematode chromosomes using a new telomere-to-telomere assembly of the rhabditin

SUBMITTER: Gonzalez de la Rosa PM 

PROVIDER: S-EPMC8022731 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature