Longitudinal fixel-based analysis reveals restoration of white matter alterations following balance training in young brain-injured patients.

ABSTRACT:

Background and objectives

Traumatic brain injury (TBI) is one of the leading causes of death and disability in children and adolescents. Young TBI patients suffer from gross motor deficits, such as postural control deficits, which can severely compromise their daily life activities. However, little attention has been devoted to uncovering the underlying white matter changes in response to training in TBI. In this study, we used longitudinal fixel-based analysis (FBA), an advanced diffusion imaging analysis technique, to investigate the effect of a balance training program on white matter fibre density and morphology in a group of young TBI patients.

Methods

Young patients with moderate-to-severe TBI (N = 17, 10 females, mean age = 13 ± 3 years) and age-matched controls (N = 

SUBMITTER: Liang X 

PROVIDER: S-EPMC8022866 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature