Pregnancies in kidney transplant recipients with complement gene variant-mediated thrombotic microangiopathy.

ABSTRACT:

Background

Pregnancies in patients with complement gene variant-mediated thrombotic microangiopathy (cTMA) are challenging, and pregnancies in such patients after kidney transplantation (KTX) are even more so.

Methods

We identified nine pregnancies following KTX of three genetically high-risk cTMA patients enrolled in the Vienna thrombotic microangiopathy cohort. Preventive plasma therapy was used in three pregnancies, and one patient had ongoing eculizumab (ECU) therapy during two pregnancies.

Results

Seven out of nine pregnancies (78%) resulted in the delivery of healthy children. The other two included one early abortion at gestational Week 12 during ongoing ECU therapy and one late foetal death at gestational Week 33 + 3, most likely not related to complement dysr

SUBMITTER: Haninger-Vacariu N 

PROVIDER: S-EPMC8023217 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature