A systematic review of the factors influencing microbial colonization of the preterm infant gut.

ABSTRACT: Prematurity coupled with the necessary clinical management of preterm (PT) infants introduces multiple factors that can interfere with microbial colonization. This study aimed to review the perinatal, physiological, pharmacological, dietary, and environmental factors associated with gut microbiota of PT infants. A total of 587 articles were retrieved from a search of multiple databases. Sixty studies were included in the review after removing duplicates and articles that did not meet the inclusion criteria. Review of this literature revealed that evidence converged on the effect of postnatal age, mode of delivery, use of antibiotics, and consumption of human milk in the composition of gut microbiota of PT infants. Less evidence was found for associations with race, sex, use of different fo

SUBMITTER: Aguilar-Lopez M 

PROVIDER: S-EPMC8023245 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature