Impact of Age on Surgical Outcomes for Locally Advanced Esophageal Cancer.

ABSTRACT:

Background

Older patients are often considered high-risk surgical candidates for locally advanced esophageal cancer, and the benefit of surgery in this population is unclear. This national analysis examines the effect of age on esophagectomy outcomes and compares surgery versus chemoradiation in older patients.

Methods

The National Cancer Database was used to identify patients with clinical stage II to III esophageal adenocarcinoma undergoing surgery or definitive chemoradiation between 2004 and 2015. Restricted cubic splines were used to examine the relationship between age and survival after esophagectomy, and maximally selected rank statistics were used to identify an age at which survival worsened. We used Cox proportional hazard models including an interaction term betw

SUBMITTER: Farrow NE 

PROVIDER: S-EPMC8023276 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature