Computer-aided diagnosis prior to conventional interpretation of prostate mpMRI: an international multi-reader study.

ABSTRACT:

Objectives

To evaluate if computer-aided diagnosis (CAD) prior to prostate multi-parametric MRI (mpMRI) can improve sensitivity and agreement between radiologists.

Methods

Nine radiologists (three each high, intermediate, low experience) from eight institutions participated. A total of 163 patients with 3-T mpMRI from 4/2012 to 6/2015 were included: 110 cancer patients with prostatectomy after mpMRI, 53 patients with no lesions on mpMRI and negative TRUS-guided biopsy. Readers were blinded to all outcomes and detected lesions per PI-RADSv2 on mpMRI. After 5 weeks, readers re-evaluated patients using CAD to detect lesions. Prostatectomy specimens registered to MRI were ground truth with index lesions defined on pathology. Sensitivity, specificity and agreement were calculated

SUBMITTER: Greer MD 

PROVIDER: S-EPMC8023433 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature