Novel anti-malarial drug strategies to prevent artemisinin partner drug resistance: A model-based analysis.

ABSTRACT: Emergence of resistance to artemisinin and partner drugs in the Greater Mekong Subregion has made elimination of malaria from this region a global priority; it also complicates its achievement. Novel drug strategies such as triple artemisinin combination therapies (ACTs) and chemoprophylaxis have been proposed to help limit resistance and accelerate elimination. The objective of this study was to better understand the potential impacts of triple ACTs and chemoprophylaxis, using a mathematical model parameterized using data from Cambodia. We used a simple compartmental model to predict trends in malaria incidence and resistance in Cambodia from 2020-2025 assuming no changes in transmission since 2018. We assessed three scenarios: a status quo scenario with artesunate-mefloquine (ASMQ) as tr

SUBMITTER: Kunkel A 

PROVIDER: S-EPMC8023453 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature