Frailty after lung transplantation is associated with impaired health-related quality of life and mortality.

ABSTRACT:

Background

Lung transplantation and related medications are associated with pathobiological changes that can induce frailty, a state of decreased physiological reserve. Causes of persistent or emergent frailty after lung transplantation, and whether such transplant-related frailty is associated with key outcomes, are unknown.

Methods

Frailty and health-related quality of life (HRQL) were prospectively measured repeatedly for up to 3 years after lung transplantation. Frailty, quantified by the Short Physical Performance Battery (SPPB), was tested as a time-dependent binary and continuous predictor. The association of transplant-related frailty with HRQL and mortality was evaluated using mixed effects and Cox regression models, respectively, adjusting for age, sex, ethnicity,

SUBMITTER: Venado A 

PROVIDER: S-EPMC8023537 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature