Exposure to Epstein Barr virus and cognitive functioning in individuals with schizophrenia.

ABSTRACT: Cognitive deficits are a central feature of schizophrenia whose etiology is not fully understood. Epstein Barr Virus (EBV) is a potentially neurotropic infectious agent that can generate persistent infections with immunomodulatory effects. Previous studies have found an association between EBV antibodies and cognitive functioning in different populations, but there has been limited investigation in schizophrenia. In this study, 84 individuals with schizophrenia were administered a comprehensive neuropsychological battery, the MATRICS Consensus Cognitive Battery (MCCB). Participants also provided a blood sample, from which antibodies to the EBV whole virion and specific proteins were measured. Multivariate models were constructed to determine the association between these antibodies and cog

SUBMITTER: Dickerson F 

PROVIDER: S-EPMC8023564 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature