Gut microbiome in Schizophrenia: Altered functional pathways related to immune modulation and atherosclerotic risk.

ABSTRACT: Emerging evidence has linked the gut microbiome changes to schizophrenia. However, there has been limited research into the functional pathways by which the gut microbiota contributes to the phenotype of persons with chronic schizophrenia. We characterized the composition and functional potential of the gut microbiota in 48 individuals with chronic schizophrenia and 48 matched (sequencing plate, age, sex, BMI, and antibiotic use) non-psychiatric comparison subjects (NCs) using 16S rRNA sequencing. Patients with schizophrenia demonstrated significant beta-diversity differences in microbial composition and predicted genetic functional potential compared to NCs. Alpha-diversity of taxa and functional pathways were not different between groups. Random forests analyses revealed that the microbi

SUBMITTER: Nguyen TT 

PROVIDER: S-EPMC8023565 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature