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Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma.

ABSTRACT: A new fluorescent biarsenical peptide labeling probe was synthesized and labeled with the radioactive isotopes 11C and 18F. The utility of this probe was demonstrated by installing each of these isotopes into a melanocortin 1 receptor (MC1R) binding peptide, which targets melanoma tumors. Its applicability was further showcased by subsequent in vitro imaging in cells as well as in vivo imaging in melanoma xenograft mice by fluorescence and positron emission tomography.

SUBMITTER: Kondrashov M 

PROVIDER: S-EPMC8023571 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma.

Kondrashov Mikhail M   Svensson Samuel P S SPS   Ström Peter P   Westermark Andreas A   Jacobson-Ingemyr Hanna H   Takano Akihiro A   Tari Lenke L   Tóth Miklós M   Cai Minying M   Hruby Victor J VJ   Schou Magnus M  

Bioconjugate chemistry 20210212 3

A new fluorescent biarsenical peptide labeling probe was synthesized and labeled with the radioactive isotopes <sup>11</sup>C and <sup>18</sup>F. The utility of this probe was demonstrated by installing each of these isotopes into a melanocortin 1 receptor (MC1R) binding peptide, which targets melanoma tumors. Its applicability was further showcased by subsequent <i>in vitro</i> imaging in cells as well as <i>in vivo</i> imaging in melanoma xenograft mice by fluorescence and positron emission to  ...[more]

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