Carboxylesterase Activities and Protein Expression in Rabbit and Pig Ocular Tissues.

ABSTRACT: Hydrolytic reactions constitute an important pathway of drug metabolism and a significant route of prodrug activation. Many ophthalmic drugs and prodrugs contain ester groups that greatly enhance their permeation across several hydrophobic barriers in the eye before the drugs are either metabolized or released, respectively, via hydrolysis. Thus, the development of ophthalmic drug therapy requires the thorough profiling of substrate specificities, activities, and expression levels of ocular esterases. However, such information is scant in the literature, especially for preclinical species often used in ophthalmology such as rabbits and pigs. Therefore, our aim was to generate systematic information on the activity and expression of carboxylesterases (CESs) and arylacetamide deacetyl

SUBMITTER: Hammid A 

PROVIDER: S-EPMC8023712 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature