Probiotic stool secretory immunoglobulin A modulation in children with gastroenteritis: a randomized clinical trial.

ABSTRACT:

Background

We previously conducted the Probiotic Regimen for Outpatient Gastroenteritis Utility of Treatment (PROGUT) study, which identified no improvements in children with acute gastroenteritis (AGE) administered a probiotic. However, the aforementioned study did not evaluate immunomodulatory benefits.

Objectives

The object of this study was to determine if stool secretory immunoglobulin A (sIgA) concentrations in children with AGE increase more among participants administered a Lactobacillus rhamnosus/helveticus probiotic compared with those administered placebo.

Methods

This a priori planned multicenter, randomized, double-blinded, placebo-controlled ancillary study enrolled children presenting for emergency care who received a 5-d probiotic or placebo course. Pa

SUBMITTER: Freedman SB 

PROVIDER: S-EPMC8023833 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature