Reward sensitivity and action in Parkinson's disease patients with and without apathy.

ABSTRACT: Clinical apathy results in dysfunction of goal directed behaviour, a key component of which is the initiation of action. Previous work has suggested that blunting of reward sensitivity is an important mechanism underlying apathy. However, an additional component might be impoverished initiation of action itself. This study aims to investigate the link between motivation and motor output and its association with apathy and dopamine. An oculomotor task that measures pupillary and saccadic response to monetary incentives was used to assess reward sensitivity, first in 23 young and 18 elderly controls, and then in 22 patients with Parkinson's disease tested ON and OFF dopaminergic medication. To distinguish between pupillary responses to anticipated reward alone versus responses associated wit

SUBMITTER: Muhammed K 

PROVIDER: S-EPMC8024004 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature