Identification of human glucocorticoid response markers using integrated multi-omic analysis from a randomized crossover trial.

ABSTRACT:

Background

Glucocorticoids are among the most commonly prescribed drugs, but there is no biomarker that can quantify their action. The aim of the study was to identify and validate circulating biomarkers of glucocorticoid action.

Methods

In a randomized, crossover, single-blind, discovery study, 10 subjects with primary adrenal insufficiency (and no other endocrinopathies) were admitted at the in-patient clinic and studied during physiological glucocorticoid exposure and withdrawal. A randomization plan before the first intervention was used. Besides mild physical and/or mental fatigue and salt craving, no serious adverse events were observed. The transcriptome in peripheral blood mononuclear cells and adipose tissue, plasma miRNAomic, and serum metabolomics were compared be

SUBMITTER: Chantzichristos D 

PROVIDER: S-EPMC8024021 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature