Molecular and functional extracellular vesicle analysis using nanopatterned microchips monitors tumor progression and metastasis.

ABSTRACT: Longitudinal cancer monitoring is crucial to clinical implementation of precision medicine. There is growing evidence indicating important functions of extracellular vesicles (EVs) in tumor progression and metastasis, including matrix remodeling via transporting matrix metalloproteases (MMPs). However, the clinical relevance of EVs remains largely undetermined, partially owing to challenges in EV analysis. Distinct from existing technologies mostly focused on characterizing molecular constituents of EVs, here we report a nanoengineered lab-on-a-chip system that enables integrative functional and molecular phenotyping of tumor-associated EVs. A generalized, high-resolution colloidal inkjet printing method was developed to allow robust and scalable manufacturing of three-dimensional (3D) nan

SUBMITTER: Zhang P 

PROVIDER: S-EPMC8024111 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature