Exploring the differentially expressed genes in human lymphocytes upon response to ionizing radiation: a network biology approach.

ABSTRACT:

Purpose

The integration of large-scale gene data and their functional analysis needs the effective application of various computational tools. Here we attempted to unravel the biological processes and cellular pathways in response to ionizing radiation using a systems biology approach.

Materials and methods

Analysis of gene ontology shows that 80, 42, 25, and 35 genes have roles in the biological process, molecular function, the cellular process, and immune system pathways, respectively. Therefore, our study emphasizes gene/protein network analysis on various differentially expressed genes (DEGs) to reveal the interactions between those proteins and their functional contribution upon radiation exposure.

Results

A gene/protein interaction network was constructed, which

SUBMITTER: Sekaran TSG 

PROVIDER: S-EPMC8024183 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature