HReg-CNCC reconstructs a regulatory network in human cranial neural crest cells and annotates variants in a developmental context.

ABSTRACT: Cranial Neural Crest Cells (CNCC) originate at the cephalic region from forebrain, midbrain and hindbrain, migrate into the developing craniofacial region, and subsequently differentiate into multiple cell types. The entire specification, delamination, migration, and differentiation process is highly regulated and abnormalities during this craniofacial development cause birth defects. To better understand the molecular networks underlying CNCC, we integrate paired gene expression & chromatin accessibility data and reconstruct the genome-wide human Regulatory network of CNCC (hReg-CNCC). Consensus optimization predicts high-quality regulations and reveals the architecture of upstream, core, and downstream transcription factors that are associated with functions of neural plate border, speci

SUBMITTER: Feng Z 

PROVIDER: S-EPMC8024315 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature