Transcriptomic signaling pathways involved in a naturalistic model of inflammation-related depression and its remission.

ABSTRACT: This study aimed at identifying molecular biomarkers of inflammation-related depression in order to improve diagnosis and treatment. For this, we performed whole-genome expression profiling from peripheral blood in a naturalistic model of inflammation-associated major depressive disorder (MDD) represented by comorbid depression in obese patients. We took advantage of the marked reduction of depressive symptoms and inflammation following bariatric surgery to test the robustness of the identified biomarkers. Depression was assessed during a clinical interview using Mini-International Neuropsychiatric Interview and the 10-item, clinician-administered, Montgomery-Asberg Depression Rating Scale. From a cohort of 100 massively obese patients, we selected 33 of them for transcriptomic analysis. T

SUBMITTER: Moisan MP 

PROVIDER: S-EPMC8024399 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature