Risk factors and outcomes for acute-on-chronic liver failure in COVID-19: a large multi-center observational cohort study.

ABSTRACT:

Objective

Coronavirus disease 2019 [COVID-19] infection in patients with chronic liver disease [CLD] may precipitate acute-on-chronic liver failure [ACLF]. In a large multi-center cohort of COVID-19-infected patients, we aim to analyze (1) the outcomes of patients with underlying CLD [with and without cirrhosis] and (2) the development and impact of ACLF on in-hospital mortality.

Design

We identified 192 adults with CLD from among 10,859 patients with confirmed COVID-19 infection (admitted to any of 12 hospitals in a New York health care system between March 1, 2020 and April 27, 2020). ACLF was defined using the EASL-CLIF Consortium definition. Patient follow-up was through April 30, 2020, or until the date of discharge, transfer, or death.

Results

Of the 84 patients

SUBMITTER: Satapathy SK 

PROVIDER: S-EPMC8024443 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature