Identification of VIMP as a gene inhibiting cytokine production in human CD4+ effector T cells.

ABSTRACT: Many players regulating the CD4⁺ T cell-mediated inflammatory response have already been identified. However, the critical nodes that constitute the regulatory and signaling networks underlying CD4 T cell responses are still missing. Using a correlation-network-guided approach, here we identified VIMP (VCP-interacting membrane protein), one of the 25 genes encoding selenoproteins in humans, as a gene regulating the effector functions of human CD4 T cells, especially production of several cytokines including IL2 and CSF2. We identified VIMP as an endogenous inhibitor of cytokine production in CD4 effector T cells via both the E2F5 transcription regulatory pathway and the Ca²⁺/NFATC2 signaling pathway. Our work not only indicates that VIMP might be a promising th

SUBMITTER: Capelle CM 

PROVIDER: S-EPMC8024663 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature