Ontology highlight
ABSTRACT:
SUBMITTER: Helland T
PROVIDER: S-EPMC8024735 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Helland Thomas T Naume Bjørn B Hustad Steinar S Bifulco Ersilia E Kvaløy Jan Terje JT Saetersdal Anna Barbro AB Synnestvedt Marit M Lende Tone Hoel TH Gilje Bjørnar B Mjaaland Ingvil I Weyde Kjetil K Blix Egil Støre ES Wiedswang Gro G Borgen Elin E Hertz Daniel Louis DL Janssen Emiel Adrianus Maria EAM Mellgren Gunnar G Søiland Håvard H
Molecular oncology 20201214 4
Low steady-state levels of active tamoxifen metabolites have been associated with inferior treatment outcomes. In this retrospective analysis of 406 estrogen receptor-positive breast cancer (BC) patients receiving adjuvant tamoxifen as initial treatment, we have associated our previously reported thresholds for the two active metabolites, Z-endoxifen and Z-4-hydroxy-tamoxifen (Z-4OHtam), with treatment outcomes in an independent cohort of BC patients. Among all patients, metabolite levels did no ...[more]