Parenteral prostanoids for severe Group 3 pulmonary hypertension with right ventricular dysfunction.

ABSTRACT:

Background

Group 3 pulmonary hypertension (PH) is a common complication in patients with lung diseases but there are currently no FDA-approved therapies. The data is conflicting, but a few small studies suggest potential benefits in using Group 1 PH therapies in these patients, particularly in severe PH with right ventricular (RV) dysfunction.

Methods

A retrospective cohort study of patients with severe Group 3 PH with RV dysfunction who received parenteral prostanoids from 2007-2018 at our institution was undertaken. Severe PH was defined as mean pulmonary arterial pressure (mPAP) ≥35 mmHg or mPAP 25-34 with cardiac index (CI) <2.4 L/min/m². Routine prognostic studies including N-terminal prohormone of brain natriuretic peptide (NT-proBNP), 6-minute walk distance

SUBMITTER: Hinkamp CA 

PROVIDER: S-EPMC8024797 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature