Antihypertensive treatment and risk of cancer: an individual participant data meta-analysis.

ABSTRACT:

Background

Some studies have suggested a link between antihypertensive medication and cancer, but the evidence is so far inconclusive. Thus, we aimed to investigate this association in a large individual patient data meta-analysis of randomised clinical trials.

Methods

We searched PubMed, MEDLINE, The Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov from Jan 1, 1966, to Sept 1, 2019, to identify potentially eligible randomised controlled trials. Eligible studies were randomised controlled trials comparing one blood pressure lowering drug class with a placebo, inactive control, or other blood pressure lowering drug. We also required that trials had at least 1000 participant years of follow-up in each treatment group. Trials without cancer event informati

SUBMITTER: Copland E 

PROVIDER: S-EPMC8024901 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature