Photoacoustic Computed Tomography of Breast Cancer in Response to Neoadjuvant Chemotherapy.

ABSTRACT: Neoadjuvant chemotherapy (NAC) has contributed to improving breast cancer outcomes, and it would ideally reduce the need for definitive breast surgery in patients who have no residual cancer after NAC treatment. However, there is no reliable noninvasive imaging modality accepted as the routine method to assess response to NAC. Because of the inability to detect complete response, post-NAC surgery remains the standard of care. To overcome this limitation, a single-breath-hold photoacoustic computed tomography (SBH-PACT) system is developed to provide contrast similar to that of contrast-enhanced magnetic resonance imaging, but with much higher spatial and temporal resolution and without injection of contrast chemicals. SBH-PACT images breast cancer patients at three time points: before, dur

SUBMITTER: Lin L 

PROVIDER: S-EPMC8025032 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature