A Robust Oxygen Microbubble Radiosensitizer for Iodine-125 Brachytherapy.

ABSTRACT: Iodine-125 (¹²⁵I) brachytherapy, a promising form of radiotherapy, is increasingly applied in the clinical treatment of a wide range of solid tumors. However, the extremely hypoxic microenvironment in solid tumors can cause hypoxia-induced radioresistance to ¹²⁵I brachytherapy, resulting in therapeutic inefficacy. In this study, the aim is to sensitize hypoxic areas in solid tumors using ultrasound-activated oxygen microbubbles for ¹²⁵I brachytherapy. A modified emulsion freeze-drying method is developed to prepare microbubbles that can be lyophilized for storage and easily reconstituted in situ before administration. The filling gas of the microbubbles is modified by the addition of sulfur hexafluoride to oxygen such that the obtained O₂/SF

SUBMITTER: Peng S 

PROVIDER: S-EPMC8025033 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature