Knockdown of PNO1 inhibits esophageal cancer progression.
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ABSTRACT:
SUBMITTER: Wang G
PROVIDER: S-EPMC8025143 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
Knockdown of PNO1 inhibits esophageal cancer progression.
Wang Guowen G Li Qicai Q Li Chuankui C Duan Guixin G Sang Haiwei H Dong Haijun H Yang Yifan Y Ma Chang C Tao Tao T
Oncology reports 20210413 5
The present study aimed to investigate the role of partner of NOB1 homolog (PNO1) in esophageal cancer (EC). The expression levels of PNO1 in EC were primarily analyzed using data obtained from databases. PNO1 expression was also knocked down in EC cells (Eca‑109 and TE1) to determine the biological effects of PNO1 on tumorigenesis <i>in vitro</i> and <i>in vivo</i>. In addition, possible downstream targets of PNO1 in EC were identified. The expression levels of PNO1 were upregulated in the tumo ...[more]
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