Multiple nutritional phenotypes of fission yeast mutants defective in genes encoding essential mitochondrial proteins.

ABSTRACT: Mitochondria are essential for regulation of cellular respiration, energy production, small molecule metabolism, anti-oxidation and cell ageing, among other things. While the mitochondrial genome contains a small number of protein-coding genes, the great majority of mitochondrial proteins are encoded by chromosomal genes. In the fission yeast Schizosaccharomyces pombe, 770 proteins encoded by chromosomal genes are located in mitochondria. Of these, 195 proteins, many of which are implicated in translation and transport, are absolutely essential for viability. We isolated and characterized eight temperature-sensitive (ts) strains with mutations in essential mitochondrial proteins. Interestingly, they are also sensitive to limited nutrition (glucose and/or nitrogen), producing

SUBMITTER: Uehara L 

PROVIDER: S-EPMC8025305 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature