Diagnostic performance of Oncuria™, a urinalysis test for bladder cancer.

ABSTRACT:

Background

Due to insufficient accuracy, urine-based assays currently have a limited role in the management of patients with bladder cancer. The identification of multiplex molecular signatures associated with disease has the potential to address this deficiency and to assist with accurate, non-invasive diagnosis and monitoring.

Methods

To evaluate the performance of Oncuria™, a multiplex immunoassay for bladder detection in voided urine samples. The test was evaluated in a multi-institutional cohort of 362 prospectively collected subjects presenting for bladder cancer evaluation. The parallel measurement of 10 biomarkers (A1AT, APOE, ANG, CA9, IL8, MMP9, MMP10, PAI1, SDC1 and VEGFA) was performed in an independent clinical laboratory. The ability of the test to identify pat

SUBMITTER: Hirasawa Y 

PROVIDER: S-EPMC8025333 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature