A signature of 24 aging‑related gene pairs predict overall survival in gastric cancer.

ABSTRACT:

Background

Aging is the major risk factor for most human cancers. We aim to develop and validate a reliable aging-related gene pair signature (ARGPs) to predict the prognosis of gastric cancer (GC) patients.

Methods

The mRNA expression data and clinical information were obtained from two public databases, The Cancer Genome Atlas (TCGA) dataset, and Gene Expression Omnibus (GEO) dataset, respectively. The best prognostic signature was established using Cox regression analysis (univariate and least absolute shrinkage and selection operator). The optimal cut-off value to distinguish between high- and low-risk patients was found by time-dependent receiver operating characteristic (ROC). The prognostic ability of the ARGPS was evaluated by a log-rank test and a Cox proportional h

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8025368 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature