Predictive factors of toxicity of TPF induction chemotherapy for locally advanced head and neck cancers.

ABSTRACT:

Background

The rate of toxic deaths related to induction chemotherapy in the treatment of locally advanced head and neck cancers is unacceptable and calls into question this therapeutic strategy, which is however highly effective in terms of rate and speed of response. The purpose of the study was to investigate predictive factors of toxicity of induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil (TPF) in locally advanced head and neck cancers (LAHNC).

Methods

Between June 2009 and December 2017, 113 patients treated consecutively with TPF were included retrospectively. Patients were receiving induction chemotherapy for either an inoperable cancer or laryngeal preservation. For inoperable cancer, induction chemotherapy was proposed to patients presenting eit

SUBMITTER: Bernadach M 

PROVIDER: S-EPMC8025378 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature