A quality improvement project to address the challenges surrounding zoledronic acid use in children.

ABSTRACT:

Introduction

Zoledronic acid (ZA) is an intravenous bisphosphonate used to treat pediatric osteoporosis. Adverse events including hypocalcemia and acute phase reaction (APR) are common following first-infusion. The purpose of this report is to describe implementation of a ZA clinical practice guideline and the subsequent process changes to improve adherence to aspects of the protocol related to safety and efficacy.

Methods

Quality assurance was evaluated by chart review over a 5-year period to compare the prevalence of hypocalcemia and APR to published data. A quality improvement (QI) initiative consisting of process changes including the addition of an endocrine RN to coordinate infusions and a shift to patient/family self-scheduling of infusions was conducted. The effect o

SUBMITTER: Weber DR 

PROVIDER: S-EPMC8025437 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature